Findings
There is a notable lack of reports on the use of digital health technology in pediatric patients.
Challenges exist in selecting the design, metrics, and types of sensors best suited for disease evaluation.
False positive detection remains problematic in seizure detection using DHTs.
There is a lack of information on the use of DHTs in infants.
Unique design challenges for pediatric DHTs arise from size, anatomy, physiology, activity levels, and cognitive development.

Recommendations
Further research and evaluation are needed to realize the full potential of remote monitoring in pediatric trials.
Creative approaches, including machine learning, should be employed to identify optimal measurement methods.
Training for caregivers is necessary to ensure DHTs are worn correctly and data are complete.

Regulatory Considerations
Confirming the reliability and clinical relevance of DHT measurements is essential.
Ensuring privacy and confidentiality of patient data must be prioritized.